Takeshi Sakurai Selected Research

Sleep Wake Disorders

10/2017	Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.
1/2017	Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity.
1/2016	Sleep Control, GPCRs, and Glucose Metabolism.
6/2015	[Roles of orexin and effects of orexin receptor antagonists].
5/2014	Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.
2/2014	Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.
10/2013	Orexin deficiency and narcolepsy.
2/2013	Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status.
1/2012	Overview of orexin/hypocretin system.
8/2011	Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal.

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Takeshi Sakurai Research Topics

Disease

40	Narcolepsy 01/2019 - 12/2002
17	Sleep Wake Disorders 10/2017 - 05/2004
15	Cataplexy 01/2017 - 03/2004
7	Insulin Resistance 01/2021 - 07/2002
7	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2021 - 08/2011
7	Substance-Related Disorders (Drug Abuse) 01/2021 - 03/2006
7	Schizophrenia (Dementia Praecox) 11/2019 - 09/2005
6	Obesity 09/2013 - 06/2005
5	Body Weight (Weight, Body) 11/2016 - 09/2006
5	Type 2 Diabetes Mellitus (MODY) 11/2016 - 09/2003
5	Coronary Artery Disease (Coronary Atherosclerosis) 01/2011 - 07/2002
4	Mental Disorders (Mental Disorder) 01/2021 - 02/2017
4	Pain (Aches) 11/2016 - 01/2008
4	Autistic Disorder (Autism) 09/2013 - 05/2009
4	Thrombosis (Thrombus) 07/2011 - 11/2010
4	Acute Coronary Syndrome 06/2011 - 09/2010
4	Myocardial Infarction 06/2010 - 01/2002
3	Disorders of Excessive Somnolence (Hypersomnia) 01/2017 - 02/2013
3	Sleep Deprivation 11/2008 - 07/2006
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2020 - 11/2017
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 05/2018 - 12/2011
2	Epilepsy (Aura) 10/2017 - 08/2012
2	Polydipsia 10/2017 - 09/2005
2	Hyponatremia 10/2017 - 09/2005
2	Glucose Intolerance 11/2016 - 06/2013
2	Inflammation (Inflammations) 11/2016 - 03/2013
2	Sleepiness 02/2014 - 07/2004
2	Hyperphagia (Overeating) 09/2013 - 05/2003
2	Necrosis 03/2013 - 06/2010
2	Non-ST Elevated Myocardial Infarction 07/2011 - 06/2011
2	Unstable Angina 07/2011 - 06/2011
2	Autism Spectrum Disorder 01/2011 - 05/2010
2	Angina Pectoris 01/2010 - 07/2002
2	Coronary Stenosis (Coronary Artery Stenosis) 01/2010 - 10/2002
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2009 - 05/2006
2	Neoplasms (Cancer) 07/2007 - 12/2005
1	Parasomnias (Parasomnia) 11/2020
1	Anxiety Disorders (Anxiety Disorder) 01/2020
1	Brain Diseases (Brain Disorder) 01/2019
1	Neuroinflammatory Diseases 11/2018
1	Cocaine-Related Disorders (Cocaine Addiction) 01/2018
1	Cluster Headache (Cluster Headaches) 10/2017
1	Alcoholism (Alcohol Abuse) 04/2017
1	Chronic Renal Insufficiency 04/2016
1	Diabetes Complications 01/2016
1	Hyperglycemia 01/2016

Drug/Important Bio-Agent (IBA)

59	OrexinsIBA 01/2021 - 12/2002
15	NeuropeptidesIBA 06/2015 - 05/2004
10	Peptides (Polypeptides)IBA 01/2021 - 03/2004
9	Orexin ReceptorsIBA 10/2017 - 03/2004
6	Pharmaceutical PreparationsIBA 11/2018 - 03/2006
6	Ataxin-3IBA 03/2013 - 05/2004
5	Insulin (Novolin)FDA Link 01/2021 - 09/2003
4	Orexin Receptor AntagonistsIBA 01/2021 - 11/2013
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2012
4	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 03/2004
4	LeptinIBA 09/2013 - 03/2004
4	Coloring Agents (Dyes)IBA 06/2011 - 01/2010
3	Messenger RNA (mRNA)IBA 11/2016 - 03/2013
3	Blood Glucose (Blood Sugar)IBA 01/2016 - 09/2003
3	LigandsIBA 08/2008 - 08/2004
2	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 10/2011
2	Cocaine (Cocaine HCl)IBA 01/2020 - 01/2018
2	suvorexantIBA 11/2016 - 02/2013
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2016 - 08/2004
2	Glutamic Acid (Glutamate)FDA Link 11/2013 - 01/2011
2	FibrinIBA 07/2011 - 06/2011
2	MetalsIBA 01/2011 - 09/2010
2	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2011 - 10/2002
2	Evans Blue (Blue, Evans)FDA Link 01/2011 - 01/2010
2	Acetylcholine (Acetylcholine Chloride)FDA Link 06/2010 - 07/2002
2	4-nitrophenethyl bromide (NPB)IBA 01/2008 - 05/2003
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 07/2002 - 01/2002
1	Amphetamine (Amfetamine)FDA LinkGeneric 01/2021
1	Transcription Factors (Transcription Factor)IBA 11/2020
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	AntibodiesIBA 11/2018
1	Methylphenidate (Ritalin)FDA LinkGeneric 05/2018
1	Guanfacine (Tenex)FDA LinkGeneric 05/2018
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 10/2017
1	Opioid Analgesics (Opioids)IBA 10/2017
1	Ethanol (Ethyl Alcohol)IBA 04/2017
1	YNT-185IBA 01/2017
1	Serotonin (5 Hydroxytryptamine)IBA 01/2017
1	linaloolIBA 11/2016
1	Monoterpenes (Monoterpenoids)IBA 11/2016
1	Analgesics (Analgesic Drugs)IBA 11/2016
1	Glucagon (Glukagon)FDA Link 11/2016
1	Triglycerides (Triacylglycerol)IBA 11/2016
1	Formaldehyde (Formol)FDA Link 05/2016
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2016
1	Cholinergic Agents (Cholinergics)IBA 01/2016
1	Nicotine FDA Link 01/2016
1	MelatoninIBA 01/2016
1	GABA Agonists (GABA Receptor Agonists)IBA 01/2016

Therapy/Procedure

13	Therapeutics 01/2018 - 12/2004
4	Stents 01/2011 - 07/2003
1	Precision Medicine 11/2019
1	Oral Administration 11/2016
1	Chronotherapy 01/2016